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Furthermore, the peptide ApoE-DBCO, capable of specifically binding to LDLR expressed on brain endothelial cells and glioma cells, was coupled to the azido group of nanoprobe through a Cu-free click cycloaddition reaction

Acknowledgements This work was partially funded by the Italian Ministry of Education (MIUR, Grant to GS) and by Sigma Tau Industrie Farmaceutiche Riunite (Grant to GR)